昨天在網路上看到一個網址分享,討論著十大寵物界的營養補助品,其中第一項提出了glucosamine針對關節炎問題並沒有功效 ,難道給予glucosamine真如文章所言是一種給心安及安慰劑的效用?
因為內文含有更多延伸閱讀,也有單討論glucosamine的文章,所以我才註明出處,方便大家連結去閱讀:(The Top Ten Pet Supplements–Do They Work?,如果不能加連結註明原處請告知,謝謝。)
該篇文章所截取的內容如下:
1. Glucosamine
The biggest name in the veterinary supplement world by a large margin is glucosamine. It is sold alone or in combination with chondroitin, MSM, green-lipped mussle extract, and a zillion other ingredients. It is sold over-the-counter and through veterinarians and as an additive in commercial pet foods, and it is ubiquitous. It is also widely believed by pet owners and veterinarians to be an effective treatment for osteoarthritis.
Glucosamine for arthritis in humans has been discussed at length here before. There is some reasonable plausibility to the underlying theory, but decades of clinical trials have failed to find any consistent benefit, and the balance of the evidence strongly suggests it is no better than a placebo in treating arthritis in humans. Given the subjective nature of pain and the multitude of ways biologically inert interventions can influence people’s perceptions of their own discomfort, this placebo effect might be of marginal value in humans, but the same kind of psychology does not apply to dogs and cats, though it certainly does apply to their owners.
There is very little clinical research on glucosamine as a treatment for arthritis in dogs and cats. In preparing a recent brief literature review, I found only two clinical trials in dogs. One found no benefit for glucosamine and the other, which had a weaker design, showed little benefit. Both showed far greater and more predictable benefit to non-steroidal anti-inflammatory (NSAID) therapy, which is a consistent feature of clinical research on glucosamine.
Because cats are poorly tolerant of NSAIDs, there is particularly great interest in glucosamine and other nutraceutical therapies for osteoarthritis in this species. Nevertheless, I have found no published clinical trials studying this supplement in arthritis cats. The closest is a study of a diet containing glucosamine, chondroitin, and a number of other supplements purported to have benefits in managing arthritis. I have addressed this study in detail elsewhere, but in brief there were not consistent differences between the experimental diet and the control diet even on subjective measures of comfort and no differences at all on objective measures of activity. And, of course, the role of glucosamine, if any, in any effect that might have been seen would not be demonstrable in a study of a diet with many other ingredients.
Glucosamine is also marketed for treatment of feline interstitial cystitis, an uncomfortable and potentially very serious chronic inflammatory disease of the urinary bladder. However, the only clinical trial to investigate this use did not find any evidence of benefit.
在市面上大部分的保健品都是複方的,而葡萄糖胺也有分類型,但看到這文章令我不解的是到底是真還是偽?我只知道針對glucosamine實在說法眾多,難道全部的葡萄糖胺都是如此?真的有效益也許是軟骨素等其它複方成份?不知道版上有誰能否提出其它專業及客觀的意見與資料,謝謝。